302        Bioinformatics

12. Rognes T, Flouri T, Nichols B, Quince C, Mahé F: VSEARCH: a versatile open source tool for

metagenomics. PeerJ 2016, 4:e2584.

13. Cole JR, Wang Q, Fish JA, Chai B, McGarrell DM, Sun Y, Brown CT, Porras-Alfaro A, Kuske

CR, Tiedje JM: Ribosomal Database Project: data and tools for high throughput rRNA analy-

sis. Nucleic Acids Res 2014, 42(Database issue):D633–642.

14. Olsen GJ: [53] Phylogenetic analysis using ribosomal RNA. In: Methods in Enzymology. vol.

164: Academic Press; 1988: 793–812.

15. Bolyen E, Rideout JR, Dillon MR, Bokulich NA, Abnet CC, Al-Ghalith GA, Alexander H,

Alm EJ, Arumugam M, Asnicar F et al: Reproducible, interactive, scalable and extensible

microbiome data science using QIIME 2. Nat Biotechnol 2019, 37(8):852–857.

16. Thompson LR, Sanders JG, McDonald D, Amir A, Ladau J, Locey KJ, Prill RJ, Tripathi A,

Gibbons SM, Ackermann G et al: A communal catalogue reveals Earth’s multiscale microbial

diversity. Nature 2017, 551(7681):457–463.